Owen Witte is the Director of the Broad Center of Regenerative Medicine and Stem Cell Research at UCLA. His work includes the discovery of tyrosine kinase activity for the ABL gene and the demonstration of the BCR-ABL oncoproteins in human leukemias, leading to the development of kinase targeted therapies. He co-discovered Bruton’s tyrosine kinase (BTK) which is required for normal B-lymphocyte development. Inhibitors for BTK are now used for the treatment of certain lymphomas and leukemias. Recent work has concentrated on studying the stem cells for epithelial cancers of the prostate to define new types of therapy. Dr. Witte is a member of the National Academy of Sciences and the Institute of Medicine.
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